Dr. Patrick's work focuses on identifying and characterizing pathogenic molecular pathways in juvenile idiopathic arthritis and pediatric autoimmune disease.  Her research program employs the study of rare monogenetic mutations associated with disease manifestations to discover novel pathways involved in autoimmunity.  This strategy defines the relationship of these pathways to the broader disease population.  She has elucidated the role of GATA3, a gene critical for T cell differentiation and function, in juvenile idiopathic arthritis.  Her research program involves studies in primary human cells using molecular biology, immunology, and next generation sequencing techniques. 

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Dr. Patel's research interests include the development of a computerized database for the PCCU for quality assurance and clinical research as well as an electronic charting system for deep sedation services in collaboration with Integrated eMed Solutions.

Dr. Parra is interested in advanced non invasive imaging to determine early markers of cardiac dysfunction in patients with congenital heart disease and cardiomyopathy

Dr. Orsagh-Yentis has a particular interest in motility disorders, having completed an advanced year of fellowship in that field. She is also passionate about advocacy and patient safety and ways to make products safer for children. She has been interviewed by The New York Times, NBC, ABC, and Nature about her work on foreign body ingestions.

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To successfully infect the tissues and hosts they encounter, viruses must efficiently bind, enter, and replicate in target cells and rapidly adapt to changing environmental pressures. Research in the Ogden lab is focused on the tropism and diversity mechanisms of RNA viruses, including rotavirus and reovirus. Rotavirus is an important cause of diarrheal disease that results in the deaths of more than a hundred thousand infants and children each year. In the Ogden Lab, we are studying functions of rotavirus outer-capsid proteins in infection and neutralization, contributions of FAST proteins to virus spread, and effects of virus transport as free particles or in extracellular vesicles. Reovirus is an oncolytic virus that is rarely associated with acute disease in humans. The Ogden Lab uses reovirus to answer fundamental questions about virus structure, virus-cell interactions, and viral diversity. Themes we explore include packaging signals, RNA recombination and defective viral genomes, gene segment reassortment during coinfection, virus egress and infection in extracellular vesicles, and structural dynamics of the attachment protein during cell entry. A long-term goal of the lab is to engineer viruses to make better vaccines, therapeutics, and research tools.

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My research focuses on the diagnostic process for PCD, specifically on the role of nasal nitric oxide (nNO) testing in making a diagnosis of PCD.