Kris P. Rehm, MD, MMHC, SFHM
Specialty
General Pediatrics
M.D.
Northwestern University, 1998
Residencies
Pediatric Residency-Boston Combined Residency Program
Pediatric Chief Resident-Boston Combined Residency Program
Specialty
General Pediatrics
M.D.
Northwestern University, 1998
Residencies
Pediatric Residency-Boston Combined Residency Program
Pediatric Chief Resident-Boston Combined Residency Program
Dr. Reese's laboratory is interested in the molecular mechanisms of embryo implantation and other aspects of reproduction. He is particularly focused on the contribution of prostaglandins and other eicosanoids to the reproductive process. Prostaglandins are key molecules in ovulation, fertilization, implantation, decidualization, and overall control of the parturition process. Dr. Reese has an extended research background in reproductive biology and the role of prostaglandins in reproduction and fetal vascular development. His lab uses Cox1, Cox2, cPLA2, prostaglandin receptor knockout mice, and other transgenic or pharmacologic models of prostaglandin deficiency. Their collaborative studies on the role of prostaglandins in cancer, atherosclerosis, cardiovascular homeostasis and neurobehavioral function reflect a broad-based approach to studies on prostaglandin biology.
>> View Publications on PubMed
Association between the antacid cimetidine and PDA
Development and disease in the aorta
Study seeks to explore drug link to fetal vessel defect
Embryo implantation, Fetal vascular biology, Maternal-fetal interactions during pregnancy, Prostaglandin biology, Regulation of the ductus arteriosus
Specialty
Neonatology
M.D.
University of Kansas, 1987
Internship
Internship 1987-1988-Vanderbilt
Residency
Residency 1988-1992-Vanderbilt
Fellowships
Fellowship 1991-1992-Monash Medical Centre, Melbourne Australia
Fellowship 1992-1995-Yale University
Specialty
General Pediatrics
M.D.
University of Mississippi School of Medicine, 2006
Internship
Pediatrics Internship-Vanderbilt University Medical Center, Nashville, TN
Residencies
Pediatrics Residency-Vanderbilt University Medical Center, Nashivlle, Tn
Pediatrics Chief Resident-Vanderbilt University Medical Center, Nashville, TN
Pediatric electrophysiology
Specialty
Cardiology, Pediatric
M.D.
University of Alabama School of Medicine, Birmingham, AL, 2003
Residencies
Intern in Pediatrics, Boston Combined Residency Program in Pediatrics-Children's Hospital Boston and Boston Medical Center, Boston, MA
Resident in Pediatrics, Boston Combined Residency Program in Pediatrics-Children's Hospital Boston and Boston Medical Center, Boston, MA
Fellowships
Fellow in Cardiology-Harvard Medical School and Children's Hospital Boston, Boston, MA
Fellow in Electrophysiology and Pacing-Harvard Medical School and Children's Hospital Boston, Boston, MA
I have a broad background in cell and developmental biology, with specific training and expertise in manipulating the mouse embryo, making mouse knock-out/transgenic models and phenotype analysis on cardiovascular system. Defining these mechanisms will be the only way in which we will someday be able to prevent the diseases from occurring. Using state-of-the-art approaches, I have generated numerous conditional floxed mouse alleles including Tie1, Tie2, Ndrg4 and Ndrg2, and point mutant allele for Tie1. These animal models are valuable for understanding mechanisms of cardiac-vasculature development. My research at VUMC in the recent 10 years has focused primarily on the roles of two transmembrane protein receptor tyrosine kinases Tie1 and Tie2 in cardiovascular development including heart chamber formation, valve remodeling and lymphatic development and how understanding these developmental mechanisms can help us understand the pathogenesis of cardiovascular disease.
Specialty
Cardiology, Pediatric
Specialty
General Pediatrics
M.D.
Medical University of South Carolina, Charleston, 1992
Residency
Pediatric Residency-Vanderbilt University Medical Center
General Pediatrics, Childhood Obesity
Specialty
General Pediatrics
M.D.
Autonomous University of Jaurez, Jaurez, Mexico, 1984
Residency
Pediatric Residency-University of Kansas Medical Center, Kansas City,
As a Clinical, Biochemical and Molecular Geneticist, Dr. Phillips has diagnosed, treated, and cared for children and adults with many genetic diseases, including congenital malformations, chromosomal, Mendelian, and metabolic disorders. He has been the principal investigator (PI) on clinical trials to treat Achondroplasia, Argininemia, Fatty Acid Oxidative Disorders, Methylmalonic Acidemia, and Phenylketonuria. These clinical trial studies contributed significant data that led to the FDA approval of four drugs to treat genetic disorders. As a clinician, Dr. Phillips contributes to the efforts of the Division of Medical Genetics and Genomic Medicine which currently sees approximately 5,000 total genetic cases annually.
Dr. Phillips has been a Subject Editor for the Online Mendelian Inheritance in Man (OMIM) database (https://www.omim.org). He has been a Co-Director of and lecturer in the American College of Medical Genetics, Genetics Review Course from 2005-present. He has also been a lecturer in the Annual McKusick Short Course in Medical and Experimental Mammalian Genetics, Jackson Lab, Bar Harbor, Maine from 1977 to present.
Dr. Phillips' past research focused on Mendelian disorders that have heterogeneous causes, reduced penetrance, and variable expression (Familial Growth Hormone Deficiency, Hereditable Pulmonary Arterial Hypertension, and Familial Pulmonary Fibrosis), as well as undiagnosed and many rare genetic diseases. He has shared in the discovery of multiple genetic disorders, the mechanisms underlying many, as well as the treatment of others. He is currently a Co-PI of the Vanderbilt Center for Undiagnosed Diseases (VCUD), a segment of the NIH Undiagnosed Disease Network (UDN). He also sees patients referred to the new Vanderbilt Undiagnosed Diseases Program (VUDP). In a recent review, it was discovered that 33% of our UDN diagnoses were not solved exclusively by exome sequencing (ES), and several methods were needed to detect and/or confirm the functional effects of the DNA variants that were missed by ES, and in some cases by genome sequencing.
Specialty
Medical Genetics
M.D.
Wake Forest University, Bowman Gray School of Medicine, 1969
Internship
Internship-Children's Hospital, Boston
Residency
Pediatric Residency-Children's Hospital Medical Center, Boston, MA
Fellowship
Human Genetics Fellowship-Johns Hopkins University School of Medicine, Baltimore, MD
Specialty
Developmental/Behavioral Pediatrics
Ph.D.
The University of Texas at Austin, 2000
Internship
Psychology Internship-University of Tennessee Health Sciences Center, Memphis, TN
Fellowship
Developmental Disabilities Postdoctoral Fellowship-University of Tennessee Boling Center for Developmental Disabilities, Memphis, TN