The lab uses a very broad array of techniques including molecular and cellular biology, state-of-the-art imaging, flow cytometry, bioinformatics, structural biology and bioengineering approaches to understand the human antibody response to major pathogens. Current studies center on Influenza, Zika, Ebola, Marburg, respiratory syncytial virus, and numerous other emerging pathogens. In addition to understanding the immunology of the response, we are dedicated to harnessing this response as a source of antibodies for protective and therapeutic applications. We are particularly interested in rapid antibody discovery methods where this human antibody-centered discovery platform can empower real-time pandemic medical countermeasure development.

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Dr. Kate Carlson, MD, MMHC, is the Medical Director of the Vanderbilt Pediatric Primary Care Clinic. Located on the 8th floor of the Children's outpatient tower, the VPPCC (or "DOT8 as it is affectionately called) serves as the medical home for 17,500 patients and primary care learning hub for 77 pediatric residents each year. Dr. Carlson's primary career focus is to increase capacity for quality pediatric care for immigrants and underserved children. She achieves this through primary clinical work ask a spanish-speaking pediatrician and education as a leader in the Spanish Language clinic on DOT8. Her scholarly work uses quality improvement methodology to standardize approaches within the clinic to improve the health of all patients, and to improve the experience of patients and providers alike through efficiency initiatives most recently related to documentation timeliness and clinic throughout.

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Lisa has a Masters of Health Policy Research with a concentration is quality improvement and patient safety. She is interested in process and care standardization, and the effects of standardization on patient- and disease-related outcomes. Specifically, she is interested in implementing consistent point-of-care documentation and review of disease activity for patients with juvenile idiopathic arthritis with the goal of using disease activity measures to adjust therapy. She is also interested in using her skills as an Epic Physician Builder to standardize documentation of disease activity (and more) to track patient- and disease-related outcomes on a population level.

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Dr. Brown is a pediatric pulmonologist with a focus in cystic fibrosis. She has collaborated in research projects evaluating the clinical care of people affected by cystic fibrosis including the development of guidelines for cystic fibrosis care and the involvement of advanced practice providers (NPs and PAs) within CF care in the US. Dr. Brown is one of the co-leaders of the Therapeutics Development Network site in the Cystic Fibrosis Center at Vanderbilt through which multi-center observational and interventional studies are performed. Dr. Brown performs research in quality improvement and leads the quality improvement work performed through the Cystic Fibrosis Pediatric Program at Vanderbilt. These quality improvement projects shape the clinical care provided for children with cystic fibrosis receiving care at Vanderbilt and have resulted in increases in pulmonary function, nutritional status, and access to guideline-driven and evidence based cystic fibrosis care. Dr. Brown has mentored interdisciplinary trainees, medical students, residents and pediatric pulmonology fellows in quality improvement work and cystic fibrosis research.

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