Dr. Rohrbough investigates the ion transport properties of the ClC-3 2 Cl-/1 H exchanger and the LRRC8 (VRAC) chloride channel, and developmental chloride conductances in the ductus arteriosus. He uses electrophysiological recordings (whole cell, perforated patch and intracellular recordings), confocal microscopy, and optical cellular recording of intracellular Cl- and pH. Dr. Rohrbough received his training in Neuroscience at the University of California Los Angeles. His earlier work focused largely on synaptic development, including the functional development of voltage-gated ion channels and multiple classes of synaptic transmitter receptors (GluR, GABAR, AChR) in vertebrate spinal neurons, and the development and genetic regulation of glutamatergic synaptic function in Drosophila.

Dr. Reising is a licensed clinical psychologist who specializes in psychosocial intervention for youth with serious health conditions and their families. Her research is clinical intervention based with a focus on stress, trauma, coping, and quality improvement regarding patient-centered care. In collaboration with clinical psychologist, Dr. Shari Neul, Dr. Reising co-created the Behavioral Hematology-Oncology Program (BHOP). BHOP program development focuses on providing evidence-based practices in the psychosocial assessment and support of youth diagnosed with cancer or hematological disorders and their families. Dr. Reising’s work is focused on development of an evidence-based psychosocial screening program with newly diagnosed oncology patients and their families, including the use of the Psychosocial Assessment Tool-2 (Pai et al., 2008). In collaboration with the Sickle Cell Disease (SCD) Team and Dr. Neul, Dr. Reising is incorporating an evidence-based cognitive screening, to aide in academic support planning and education of patients, families, and school personnel regarding the impact of SCD on learning and to ensure appropriate supports are in place to optimize academic and psychosocial functioning. Additionally, Drs. Reising and Neul are implementing quality improvement processes to improve access to psychosocial supports for patients with SCD and their families. Dr. Reising's quality improvement and program development efforts aim to provide evidence-based psychosocial assessment and intervention individually tailored to patient and family needs to optimize psychological adjustment and health outcomes.

Dr. Reese's laboratory is interested in the molecular mechanisms of embryo implantation and other aspects of reproduction. He is particularly focused on the contribution of prostaglandins and other eicosanoids to the reproductive process. Prostaglandins are key molecules in ovulation, fertilization, implantation, decidualization, and overall control of the parturition process. Dr. Reese has an extended research background in reproductive biology and the role of prostaglandins in reproduction and fetal vascular development. His lab uses Cox1, Cox2, cPLA2, prostaglandin receptor knockout mice, and other transgenic or pharmacologic models of prostaglandin deficiency. Their collaborative studies on the role of prostaglandins in cancer, atherosclerosis, cardiovascular homeostasis and neurobehavioral function reflect a broad-based approach to studies on prostaglandin biology.

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I have a broad background in cell and developmental biology, with specific training and expertise in manipulating the mouse embryo, making mouse knock-out/transgenic models and phenotype analysis on cardiovascular system. Defining these mechanisms will be the only way in which we will someday be able to prevent the diseases from occurring. Using state-of-the-art approaches, I have generated numerous conditional floxed mouse alleles including Tie1, Tie2, Ndrg4 and Ndrg2, and point mutant allele for Tie1. These animal models are valuable for understanding mechanisms of cardiac-vasculature development. My research at VUMC in the recent 10 years has focused primarily on the roles of two transmembrane protein receptor tyrosine kinases Tie1 and Tie2 in cardiovascular development including heart chamber formation, valve remodeling and lymphatic development and how understanding these developmental mechanisms can help us understand the pathogenesis of cardiovascular disease. 

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