Dr. Aamodt’s research focuses on the microenvironmental, molecular and genetic factors involved in development of the endocrine pancreas and diabetes pathophysiology with the goal of identifying new strategies to treat diabetes.

Diabetes is a worsening health crisis not only in the adult population but also with increasing incidence of both type 1 (T1D) and type 2 (T2D) diabetes in the pediatric population. It is often during the first decade of life when patients begin to develop β cell-directed autoimmunity (T1D) or manifest reduced β cell capacity to compensate for insulin resistance (T2D). Pancreatic development is ongoing during this pediatric period including establishment of β cell mass, functional β cell and islet maturation, and dynamic changes in islet composition and architecture. Using a multiomics approach, Dr. Aamodt is working to define the spatial and temporal molecular processes that regulate postnatal pancreas and islet development which is a critical step toward developing new diagnostic tools and strategies for prevention and treatment of both T1D and T2D.

Dr. Cassini's research focuses on finding diagnoses for individuals who have not been diagnosed via typical clinical evaluation and testing. This is accomplished through multidisciplinary specialist evaluations, novel bioinformatics techniques, emerging testing technologies, and collaborative basic science research. This approach also has the potential to further scientific understanding of disease mechanisms, such as new disease gene associations and validation of variant pathogenicity.

>> View Publications on PubMed

Dr. Dehority's research interests include chronic osteomyelitis and vaccine hesitancy. He is interested in developing a systematic approach to understanding and defining clinical presentations of chronic osteomyelitis. Ultimately, such a framework could be used to design prospective studies to optimize management approaches for this disease. Additionally, he is interested in developing widely-accessible, brief, and engaging point-of-care interventions to educate and foster discussion among vaccine-hesitant individuals, and ultimately, increase vaccine confidence, particularly in rural and underserved populations.

>> View Publications on PubMed

Dr. Brown’s research interests involve using the electronic medical record to streamline medical care. He works to guide clinical decision-making within the electronic medical record and minimize utilization of unnecessary medical testing and intervention.