Dr. Jacob Kaslow's research focuses on children who are technology dependent for respiratory support, including those with neuromuscular diseases and chronic respiratory failure. His primary interests are improving the care and quality of life in children who require mechanical ventilation through a tracheostomy. Dr. Kaslow is a founding member of a regional children's hospital collaboration to assess, develop and implement improved outpatient management of patients on mechanical ventilation. He also works to identify and promote alternative ways to improve the delivery of care to these patients and their families/caregivers.

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Dr. Smith is a junior investigator with clinical and research interests in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), myelodysplastic syndromes (MDS), and bone marrow failure disorders. She participates in the Aplastic anemia, Inherited bone marrow failure, Myeloid disorder (AIM) clinic, which offers care for patients with rare disorders of bone marrow failure and myeloid disease. She participates in the Children’s Oncology Group (COG) CML working group where she is involved in the development of clinical trials for myeloid disease. She has a specific interest in designing thoughtful, mechanistic-driven therapies for patients in clinical trials by bridging the gap between basic science laboratories and the clinic. To that end, she spent several years in the basic science laboratory of Dr. Michael Savona, using targeted therapeutics to overcome venetoclax (VEN) resistance in the treatment of AML. She also participated in the pre-clinical development of a novel inhibitor of WDR5 alongside the Fesik and Tansey laboratories. These novel inhibitors are now entering early-phase clinical trials for the treatment of hematologic and solid tumor malignancies.

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