Dan
M.
Roden
MD
Medicine, Pharmacology, and Biomedical Informatics
Sam L. Clark, MD, PhD Endowed Chair
Senior Vice President for Personalized Medicine
Office Address
1285 MRB4 (0575)
Nashville
Tennessee
37232-0575
Abnormalities of cardiac rhythm are a common and serious public health problem. However, the therapies used to treat arrhythmias are often ineffective, and can sometimes even exacerbate arrhythmias. Research in this laboratory is directed at elucidating mechanisms underlying abnormalities of cardiac rhythm and mechanisms underlying variable responses to antiarrhythmic drug treatments. Since antiarrhythmic drugs affect the function of cardiac ion channels, it is one working hypothesis in the laboratory that variable responses to drug therapy may reflect variable function or expression of genes encoding ion channels or proteins involved in drug disposition. Thus, a major focus of work in the laboratory is elucidation of factor(s) that determine ion channel gene expression in cardiac tissue. Approaches include identification of new genes, identification of DNA polymorphisms and characterization of their functional effects on disease and drug responses, and modulation of expression in cultured heart cells (e.g. by antisense) and gene knockout in mice.
>> View Publications In PubMed
dan.roden@vumc.org
Arrhythmia and Electrophysiology, Arrhythmias, Cardiovascular Medicine, Hypertrophic Cardiomyopathy & Inherited Disease
M.D.
McGill University
Internship
Royal Victoria Hospital, 1975
Residency
Royal Victoria Hospital, 1978
Fellowship
Vanderbilt University Medical Center, 1981
Board and Certifications
- Internal Medicine - American Board of Internal Medicine, 1978
- Cardiovascular Disease - American Board of Internal Medicine, 1981
- Clinical Pharmacology - American Board of Clinical Pharmacology, 1993
