Resources
Vanderbilt Neonatal Clinical Repository
The Vanderbilt Neonatal Clinical Repository (VNCR) is linked to Synthetic Derivative and contains curated data on over 15,000 NICU patients. Over 900 of these records contain Whole Exome or Genome Wide DNA data. For more information, please contact Jennifer Sucre at jennifer.sucre@vumc.org.
Precision Medicine in Pediatric Cardiology (PMPC) Cohort
The PMPC cohort includes over 2,500 children who have undergone > 3,500 surgeries for congenital heart disease at the Monroe Carell Jr. Children's Hospital at Vanderbilt. Post-operative outcomes are contained in an extensive study database and all have DNA samples, most with existing genome-wide data. For more information, please contact pedsprecisionmedicine@vumc.org.
Selected Publications
Williams ML, Kannankeril PJ, Breeyear JH, Edwards TL, Van Driest SL, Choi L. Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population. Clin Pharmacol Ther. 2022 Apr;111(4):896-908. doiPMID: 34877660; PMCID: PMC8940650.
James NT, Breeyear JH, Caprioli R, Edwards T, Hachey B, Kannankeril PJ, Keaton JM, Marshall MD, Van Driest SL, Choi L. Population pharmacokinetic analysis of dexmedetomidine in children using real-world data from electronic health records and remnant specimens. Br J Clin Pharmacol. 2022 Jun;88(6):2885-2898. PMID: 34957589; PMCID: PMC9106818.
Breeyear JH, Keaton JM, Torstenson ES, Smith AH, Klarin D, Damrauer SM, Natarajan P, Van Driest SL, Weiner JG, Kannankeril PJ, Edwards TL. Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes. Circ Res. 2022 Apr;130(7):1030-1037. PMID: 35199555; PMCID: PMC9811841.
Sunthankar SD, Kannankeril PJ, Gaedigk A, Radbill AE, Fish FA, Van Driest SL. Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population. Clin Transl Sci. 2022 Jul;15(7):1787-1795. PMID: 35514162; PMCID: PMC9283732.
Kikano S, Breeyear J, Aka I, Edwards TL, Van Driest SL, Kannankeril PJ. Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery. Am Heart J. 2022 Dec;254:57-65. PMID: 35988586.
Kikano S, Kannankeril PJ. Precision Medicine in Pediatric Cardiology. Pediatr Ann. 2022 Oct;51(10):e390-e395. PMID: 36215086.
Pilot Funding
Vanderbilt University Medical Center is a member of the MPRINT Hub, which serves as a national resource to conduct and foster therapeutics-focused research in obstetrics, lactation, and pediatrics while enhancing inclusion of people with disabilities. The MPRINT Hub is accepting applications to its Support Pool. The Support Pool is designed to fund innovative pilot or feasibility studies, or studies that address emerging needs or gaps in ongoing MPRINT projects. The goals of the study must align with the MPRINT mission, which is to foster and improve precision therapeutics in obstetrics, lactation, and pediatrics.
- Support Pool Awards are managed by the VUMC and UCSD MPRINT sites.
- If you are interested in applying for Support Pool funding, please visit the MPRINT website for more information.
