Sam is from the suburbs of Chicago. She received a BS in Chemistry and a BA in Mathematical Statistics from Wake Forest University. She attended medical school at Rush Medical College followed by a pediatric residency at the University of Chicago. During residency, she also completed the McLean Center for Clinical Medical Ethics Fellowship.

She is interested in research involving bioethics, extremely premature infants, and neonatal palliative care. In her free time, she enjoys spending time with family and friends, exploring Nashville, and traveling.