Dr. Aamodt’s research focuses on the microenvironmental, molecular and genetic factors involved in development of the endocrine pancreas and diabetes pathophysiology with the goal of identifying new strategies to treat diabetes.

Diabetes is a worsening health crisis not only in the adult population but also with increasing incidence of both type 1 (T1D) and type 2 (T2D) diabetes in the pediatric population. It is often during the first decade of life when patients begin to develop β cell-directed autoimmunity (T1D) or manifest reduced β cell capacity to compensate for insulin resistance (T2D). Pancreatic development is ongoing during this pediatric period including establishment of β cell mass, functional β cell and islet maturation, and dynamic changes in islet composition and architecture. Using a multiomics approach, Dr. Aamodt is working to define the spatial and temporal molecular processes that regulate postnatal pancreas and islet development which is a critical step toward developing new diagnostic tools and strategies for prevention and treatment of both T1D and T2D.