Justin M. Gregory, MD, MSCI
University of Tennessee Health Sciences, Memphis, TN, 2008
Pediatric Residency-University of Tennessee, LeBonheur Children's Medical Center, Memphis, TN
Pediatric Endocrinology Fellowship-Vanderbilt University Medical Center, Nashville, TN
Type 1 diabetes; glucose metabolism; iatrogenic hyperinsulinemia; insulin resistance; endothelial dysfunction
Dr. Gregory's type 1 diabetes research seeks to mechanistically define the deleterious metabolic and cardiovascular effects of iatrogenic hyperinsulinemia caused by peripheral insulin delivery. He is working to translate these findings into therapeutic strategies that will restore an appropriate balance of insulin between the liver and insulin-sensitive peripheral tissues, such as hepatopreferential and oral insulin analogs and intraperitoneal insulin delivery. Ultimately, he aims to quantify the cardiovascular benefits gained when the appropriate insulin balance between hepatic and peripheral tissues is restored. Dr. Gregory's research utilizes the conscious, catheterized canine model to manipulate metabolic and hormonal conditions in vivo. He also conducts cardiometabolic research in humans in the Clinical Research Center at Vanderbilt.