Dr. Walker performs research through the Pathology, Microbiology, and Immunology Department (Transfusion Medicine and Coagulation) and the Pediatric Department (Pediatric Hematology and Vanderbilt Vaccine Research Program). Her research focuses on pediatric hemostasis and thrombosis, predictive modeling, clinical trial design and execution, and hematology-related vaccine complications.

Dr. Siricilla's research is focused on identifying novel therapeutic agents to manage infection-induced preterm birth and protecting the fetus against in-utero inflammation. The approaches include a large-scale screening of a customized library of molecules targeting the druggable transcriptome associated with infection-induced inflammation leading to preterm birth.

Dr. Siricilla's doctoral work focused on the discovery of novel antibacterial molecules with molecular targets against problematic pathogens such as Mycobacterium tuberculosis and multidrug-resistant nosocomial pathogens. She joined the Herington Lab in 2017 as a postdoctoral fellow where Dr. Siricilla worked on projects entailing a phenotypic high-throughput screen of large compound libraries to identify novel small molecules and molecular targets that regulate uterine myometrial contractions with high selectivity. She has developed a combination high-throughput assay to identify synergistic drug combinations to improve their tocolytic efficacy and therapeutic index. She has identified a natural product, mundulone, and FDA-approved drugs with tocolytic efficacy in mono- and combination therapy with current tocolytics.