James E. Cassat, MD, PhD

James E. Cassat, MD, PhD

Assistant Professor of Pediatrics
Pediatric Infectious Diseases
Medical Center North
1161 21st Avenue South
Room / Suite
D-7235
Nashville
Tennessee
37232-9559
Phone
(615) 936-6494

Specialty
Infectious Diseases, Pediatric
M.D.
University of Arkansas for Medical Sciences, Little Rock, AR, 2008
Ph.D.
University of Arkansas for Medical Sciences, Little Rock, AR, 2008
Residency
Pediatric Residency-Vanderbilt University Medical Center, Nashville, TN
Fellowship
Pediatric Infectious Diseases Fellowship-Vanderbilt University Medical Center, Nashville, TN

Clinical Interests

Pediatric Infectious Diseases, Osteomyelitis, Musculoskeletal Infection

Research Information

The Cassat lab studies host-pathogen interactions during invasive bacterial infections, with a specific focus on osteomyelitis. We are also interested in how inflammation and the microbiome impact skeletal cell biology. Finally, we study interconnections between the vertebrate immune and skeletal systems. Current projects include: the study of how S. aureus survives within bone, delineating how co-infecting pathogens shape staphylococcal physiology and virulence during osteomyelitis, discovering how host responses to bacterial pathogens in bone shape bone remodeling, creating new molecular imaging protocols to study the host-pathogen interface during osteomyelitis, elucidating how host comorbidities such as hyperglycemia impact osteomyelitis pathogenesis, and deciphering how inflammatory bowel disease (IBD) and the gut microbiota alter bone homeostasis.

>> View Publications on PubMed