Fred S. Lamb, MD, PhD
Critical Care, Pediatric
Universtiy of Michigan, Ann Arbor, MI, 1989
University of Michigan, Ann Arbor, MI, 1989
Pediatric Residency -Mott Childrens Hospital, University of Michigan Medical School, Ann Arbor, MI
Pediatric Cardiology Fellowship-University of Iowa Hospitals and Clinics, Iowa City, Iowa
Cardiac Critical Care
Dr. Lamb's research has two primary areas of interest. The first is the molecular biology of TNF-alpha signaling, specifically on how reactive oxygen (superoxide anion) produced by NADPH oxidase 1 (Nox1) in response to this cytokine supports signaling both at the cell surface and inside of endosomes. We have demonstrated that proper localization and function of Nox1 requires anion transporters, including the ClC-3 chloride/proton anti-porter and LRRC8 family anion channels. Current efforts are focused on defining the biophysical and biochemical properties of these proteins and determining the mechanisms by which they modulate TNF-alpha signaling. They may represent useful pharmacologic targets for anti-inflammatory therapy.