Dr. Lamb is interested in how LRRC8 family anion channels support and regulate reactive oxygen species-dependent cytokine signaling in vascular smooth muscle cells. Disrupting the expression or function of these channels reduces extracellular production of superoxide anion by NADPH oxidase 1 (Nox1). This superoxide is required for signaling by molecules such as TNFα, IL-1β and bacterial endotoxin that promote inflammation. Movement of superoxide into cells via LRRC8 channels can also promote oxidative stress and cell injury. The Lamb lab is working to understand if inhibition of these channels can provide protection from both acute (sepsis), and chronic (hypertension, diabetes, atherosclerosis) vascular dysfunction.

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