Nathan Bingham, MD, PhD
University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas, TX, 2007
University of Texas Southwestern Medical School, Dallas, TX, 2008
Pediatric Residency-Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Pediatric Endocrinology Fellowship-Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Prader-Willi Syndrome, Type 1 Diabetes, Type 2 Diabetes, Thyroid disorders, Adrenal disorders, Puberty disorders, short stature
Diets rich in fat content have been shown to induce a state of chronic, low-grade inflammation within the hypothalamus, a brain region critical in the regulation of appetite and body weight. This inflammation has been shown to disrupt the normal functions of the hypothalamus, altering the hormonal and neuronal signals that regulate energy balance and contributing to continued weight gain. The Bingham lab uses mouse models of obesity to evaluate the mechanisms leading to the development of high-fat diet-induced hypothalamic inflammation. In addition, we use mouse models of bariatric surgery to evaluate the effects that this common obesity treatment has on hypothalamic inflammation. We hope that these tools will lead to a better understanding of the cellular and molecular mechanisms that contribute to the development of hypothalamic inflammation and lead to novel treatments for obesity.