Michael Miller, MD, PhD
University of Iowa Roy J. and Lucille A. Carver College of Medicine, 2007-2015
Pediatrics - Vanderbilt University Medical Center, 2015-2018
Pediatric Critical Care - Vanderbilt University Medical Center, 2018-2021
Acute respiratory distress syndrome
Dr. Miller’s research focuses on the effects of the redox environment, its modulators, and their functional outcome on cellular and animal models of acute respiratory distress syndrome (ARDS). His work is focused on building upon the molecular pathways associated with the inflammatory response characteristic of the development of ARDS. Specifically, he is investigating extracellular superoxide dismutase (ecSOD), an enzyme the catalyzes superoxide to hydrogen peroxide, and how ecSOD modulates pro-inflammatory signaling in the NF-kB pathway. Additionally, he is seeking to determine the functional implications of ecSOD localization, its role in endothelial dysfunction, and how its interaction with the extracellular matrix alters its signaling properties.