The Denison Lab studies the coronaviruses (CoVs), specifically Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). They work to define the mechanisms of virus evolution and adaptation. Ongoing projects include studies of a unique virus-encoded RNA proofreading enzyme in coronavirus evolution and disease, studies of potential therapeutic monoclonal antibodies, and testing of highly active antiviral nucleoside analogs against all CoVs. Dr. Denison has trained graduate students, postdocs, medical students, undergraduates and faculty in virology research. Dr. Denison directs a T32 (training grant) for ID Fellows and postdoctoral scientists, and is a training director for the Pediatrics K12 physician-scientist training grant.

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